<p><span style="font-size: 24px;"><strong><span style="color: rgb(128, 100, 162);">INDICATION</span></strong></span><span style="font-size: 16px;"><span style="font-size: 20px;"><strong><br></strong>Lexiscan is a pharmacologic stress agent indicated for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress.</span></span><strong><span style="color: rgb(128, 100, 162); font-size: 10px;"><br></span></strong></p><p><span style="font-size: 20px;"><span style="font-size: 24px;"><strong><span style="color: rgb(128, 100, 162);">IMPORTANT SAFETY INFORMATION<br></span></strong><strong><span style="color: rgb(128, 100, 162);">CONTRAINDICATIONS</span></strong></span></span><span style="font-size: 20px;"><br>Do not administer Lexiscan to patients with second- or third-degree AV block or sinus node dysfunction unless these patients have a functioning artificial pacemaker.</span><span style="font-size: 24px;"><br><strong></strong><strong><br></strong><strong>PLEASE SEE ADDITIONAL IMPORTANT SAFETY INFORMATION BELOW.<br></strong><strong>PLEASE SEE FULL </strong><strong><a href="https://www.astellas.us/docs/lexiscan.pdf?utm_source=branded_booth&utm_medium=website&utm_campaign=asnc_2020&utm_content=pi" target="_blank">PRESCRIBING INFORMATION</a></strong></span><strong><span style="font-size: 24px;"> FOR LEXISCAN.</span><br></strong><span style="font-size: 20px;"><strong><br></strong></span></p><p><span style="font-size: 20px;"><strong><span style="font-size: 24px;">Visit <a href="https://www.astellasmedinfo.com?utm_source=branded_booth&utm_medium=website&utm_campaign=asnc_2020&utm_content=info_form" target="_blank">Astellas Medical Information</a> to submit a Medical Information Request Form.</span></strong></span><span style="font-size: 24px;"><br><span style="color: rgb(128, 100, 162); font-size: 20px;"><strong><span style="font-size: 10px;"></span><br><br></strong></span><span style="color: rgb(128, 100, 162); font-size: 20px;"><span style="font-size: 10px;"></span></span></span><span style="text-align: justify; font-size: 20px; color: rgb(128, 100, 162);"><strong><strong style="color: rgb(128, 100, 162); font-size: 20px;"><span style="font-size: 24px;">Astellas Is Committed to Helping Support the Nuclear Cardiology Community During COVID-19 by Providing a Link to the ASNC, IAEA, and SNMMI Information Statement</span></strong><br></strong></span></p><a href="https://bit.ly/2EXDFkS" target="_blank"><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/788899f4fc37f7937b78aa8718ed9cb0.png" data-image="765te5w50kya" class="img-responsive center-block" alt="Download the COVID-19 Information Statement" title="custom image"></a><p><span style="text-align: justify; font-size: 20px; color: rgb(128, 100, 162);"><span style="font-size: 16px;"></span></span><span style="text-align: justify; font-size: 20px; color: rgb(128, 100, 162);"><span style="font-size: 14px;"><span style="font-size: 16px;"><span style="font-size: 18px;"><span style="color: rgb(0, 0, 0);">By clicking the link above, you are leaving the Lexiscan Virtual Booth. The document you are linking to is neither owned nor controlled by Astellas. Astellas is not responsible for its contents.</span></span></span></span><br></span></p><p><span style="text-align: justify; font-size: 20px; color: rgb(128, 100, 162);"><strong><br></strong></span></p><p><span style="text-align: justify; font-size: 24px; color: rgb(128, 100, 162);"><strong>SIMPLIFY THE STRESS<sup>®<span style="font-size: 16px;"><span style="font-size: 20px;"><br></span></span></sup></strong></span><span style="font-size: 16px;"><span style="font-size: 20px;">Lexiscan can help simplify the pharmacologic stress process for MPI testing and help keep the nuclear lab running smoothly.<sup>1</sup></span></span><span style="font-size: 20px;"></span></p><p><br></p><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/b864bb96593cb8b5378f8b71e8f56752.png" data-image="fe799u24u7t7" class="img-responsive" alt="custom image" title="custom image"><p><strong><span style="color: rgb(128, 100, 162);"></span></strong></p><p><strong><strong><span style="color: rgb(128, 100, 162);"><span style="font-size: 16px;"><span style="font-size: 20px;">Lexiscan and tracer are administered in 1 minute.<sup>1</sup></span></span></span></strong></strong></p><p><span style="font-size: 20px;"><strong></strong></span></p><p><strong></strong></p><p><strong></strong></p><p></p><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/0383186fd87b570ea9017fc368c75f3b.png" data-image="me12vpp75sf5" class="img-responsive" alt="Lexiscan: 1-minute administration protocol" title="custom image"><p><span style="font-size: 14px;"><strong><span style="font-size: 10px;"></span></strong></span></p><p><span style="font-size: 24px; color: rgb(128, 100, 162);"><strong><strong><strong>SELECT SAFETY INFORMATION<span style="color: rgb(0, 0, 0);"><span style="font-size: 16px;"><span style="font-size: 20px;"><br></span></span></span></strong></strong></strong></span><span style="font-size: 16px;"><span style="font-size: 20px;"><strong><span style="color: rgb(128, 100, 162);"></span></strong>Adhere to the recommended duration of injection for Lexiscan. As noted in an animal study, longer injection times may increase the duration and magnitude of increase in coronary blood flow.</span></span></p><p></p><p></p><p><span style="font-size: 20px;"><strong><span style="color: rgb(128, 100, 162);"><span style="font-size: 24px;">IMPORTANT SAFETY INFORMATION (CONTINUED)<br><strong><span style="color: rgb(128, 100, 162);">WARNINGS AND PRECAUTIONS</span></strong></span></span></strong></span><span style="font-size: 16px;"><span style="font-size: 20px;"><strong><br>Myocardial Ischemia</strong><br>Fatal and nonfatal myocardial infarction, ventricular arrhythmias, and cardiac arrest have occurred following Lexiscan injection. Avoid use in patients with symptoms or signs of acute myocardial ischemia, for example unstable angina or cardiovascular instability; these patients may be at greater risk of serious cardiovascular reactions to Lexiscan. Cardiac resuscitation equipment and trained staff should be available before administering Lexiscan. Adhere to the recommended duration of injection. As noted in an animal study, longer injection times may increase the duration and magnitude of increase in coronary blood flow. If serious reactions to Lexiscan occur, consider the use of aminophylline, an adenosine antagonist, to shorten the duration of increased coronary blood flow induced by Lexiscan.</span></span></p><p><span style="font-size: 16px;"><span style="font-size: 20px;"><span style="font-size: 10px;"><br></span></span></span></p><p><span style="font-size: 24px;"><span style="font-size: 16px;"><span style="font-size: 20px;"><span style="font-size: 10px;"><strong></strong></span></span></span><span style="font-size: 20px;"><strong></strong></span></span></p><p><span style="font-size: 24px;"><strong>PLEASE SEE ADDITIONAL IMPORTANT SAFETY INFORMATION BELOW.<br></strong><strong>PLEASE SEE FULL </strong><strong><a href="https://www.astellas.us/docs/lexiscan.pdf?utm_source=branded_booth&utm_medium=website&utm_campaign=asnc_2020&utm_content=pi" target="_blank">PRESCRIBING INFORMATION</a></strong></span><strong><span style="font-size: 24px;"> FOR LEXISCAN.</span></strong></p><p><strong><span style="font-size: 20px;"></span></strong></p><p></p><p><strong><span style="font-size: 24px;"><span style="font-size: 20px;"></span></span></strong><br><span style="font-size: 20px;"></span><br></p><p></p><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/83724c83b8d3adf95b08b06309955c1e.png" data-image="gkpmx3m3kusr" class="img-responsive" alt="custom image" title="custom image"><p><strong><strong><span style="color: rgb(128, 100, 162);"></span></strong></strong></p><p><strong><strong><strong><span style="color: rgb(128, 100, 162);"><span style="font-size: 16px;"><span style="font-size: 20px;">Lexiscan is the only standard-dose, ready-to-use, pharmacologic stress agent in a prefilled syringe.<sup>1,a</sup></span></span></span></strong></strong></strong><br><sup><span style="font-size: 14px;"><span style="font-size: 12px;"><span style="font-size: 10px;"></span></span></span></sup></p><figure><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/f5da56deb702bfd988b70e35c5e115c3.png" data-image="htt2s24rtpre" class="img-responsive" alt="SIMPLIFY THE STRESS®" title="custom image"></figure><p><sup><span style="font-size: 12px;"> <span style="font-size: 14px;"><span style="font-size: 16px;"><br></span></span></span></sup><span style="font-size: 12px;"><span style="font-size: 14px;"><span style="font-size: 16px;"><sup>a</sup>Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not administer Lexiscan if it contains particulate matter or is discolored.</span></span><br></span></p><p><br></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/09c6edcc9711ea6fa49e82a4d1d81f73.png" data-image="nhlqmrhc7ms1" class="img-responsive" alt="custom image" title="custom image"><p><span style="color: rgb(128, 100, 162);"></span></p><p><strong><strong><strong><span style="color: rgb(128, 100, 162);"></span></strong></strong></strong></p><p><strong><strong><strong><strong><span style="color: rgb(128, 100, 162); font-size: 20px;">Lexiscan requires<sup>1</sup>:</span></strong><span style="font-size: 20px;"><br></span></strong></strong></strong></p><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/a0c2817e40b14ab3e4e6ed7c6f5e9c40.png" data-image="b8t0vq7zdtnm" class="img-responsive" alt="Lexiscan requires Lexiscan requires NO weight-based dosing calculations, NO drawing up dose from vial, NO pump with timed drug infusion or special IV sets, NO infusion pump batteries or replacement costs, and NO disposable items2" title="custom image"><p><strong><strong><strong><strong><span style="color: rgb(128, 100, 162); font-size: 20px;"></span></strong></strong></strong></strong></p><p><span style="font-size: 20px;"><strong><span style="color: rgb(128, 100, 162);"></span></strong></span></p><p><span style="font-size: 20px;"><strong><span style="color: rgb(128, 100, 162);"><span style="font-size: 24px;">IMPORTANT SAFETY INFORMATION (CONTINUED)<br><strong><span style="color: rgb(128, 100, 162);">WARNINGS AND PRECAUTIONS</span></strong></span></span></strong><strong><span style="color: rgb(128, 100, 162);"><strong><span style="color: rgb(128, 100, 162);"></span></strong></span></strong></span><span style="font-size: 16px;"><span style="font-size: 20px;"><strong><br>Sinoatrial and Atrioventricular Nodal Block<br></strong><strong><strong></strong></strong>Adenosine receptor agonists, including Lexiscan, can depress the SA and AV nodes and may cause first-, second-, or third-degree AV block, or sinus bradycardia requiring intervention. In postmarketing experience, heart block (including third degree), and asystole within minutes of Lexiscan administration have occurred.</span></span></p><p></p><p><span style="font-size: 16px;"><span style="font-size: 20px;"><strong><strong><strong>Atrial Fibrillation/Atrial Flutter</strong><br></strong></strong>New-onset or recurrent atrial fibrillation with rapid ventricular response and atrial flutter have been reported following Lexiscan injection.</span></span></p><p><strong><span style="font-size: 24px;"><br></span></strong></p><p><span style="font-size: 24px;"><strong>PLEASE SEE ADDITIONAL IMPORTANT SAFETY INFORMATION BELOW.<br></strong><strong>PLEASE SEE FULL </strong><strong><a href="https://www.astellas.us/docs/lexiscan.pdf?utm_source=branded_booth&utm_medium=website&utm_campaign=asnc_2020&utm_content=pi" target="_blank">PRESCRIBING INFORMATION</a></strong><strong> FOR LEXISCAN.</strong></span><span style="font-size: 24px;"><br><br><br><span style="font-size: 24px;"><strong><span style="color: rgb(128, 100, 162);">Watch the Dosing and Administration Video</span></strong></span></span></p><p></p><div class="embed-responsive embed-responsive-16by9"><figure><iframe src="https://player.vimeo.com/video/454018981" style="border: 7px solid #702f8a;" frameborder="0" allow=" fullscreen" allowfullscreen="yes" class="embed-responsive-item" scrolling="no"></iframe></figure></div><p><br></p><p></p><p><strong><span style="font-size: 20px; color: rgb(128, 100, 162);"></span></strong></p><p><span style="font-size: 24px;"><strong><span style="font-size: 20px; color: rgb(128, 100, 162);"><br></span></strong><strong><span style="font-size: 24px; color: rgb(128, 100, 162);"><br></span></strong></span></p><p><span style="font-size: 24px;"><strong><span style="font-size: 24px; color: rgb(128, 100, 162);">Learn More About How Lexiscan Administration Can Help Support Your Nuclear Lab</span></strong></span><br></p><a href="https://lexiscan.com?utm_source=branded_booth&utm_medium=website&utm_campaign=asnc_2020&utm_content=visit_button" target="_blank"><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/cdedd417efe217eed666599cbc69df7c.png" data-image="yhy2otcyxf8s" class="img-responsive center-block" alt="Visit Lexiscan.com" title="custom image"></a><p><span style="font-size: 24px;"><span style="font-size: 20px;"><span style="color: rgb(128, 100, 162);"><strong><span style="font-size: 20px; color: rgb(128, 100, 162);"></span></strong></span></span><strong style="color: rgb(128, 100, 162); font-size: 20px;"><br></strong><br><span style="font-size: 20px;"><span style="color: rgb(128, 100, 162);"><strong><br></strong></span></span><span style="font-size: 24px; color: rgb(128, 100, 162);"><strong>Download Digital Resources to Help Patients Prepare for a Nuclear Stress Test</strong></span></span></p><a href="https://lexiscan.com/Resources/PatientResources?utm_source=branded_booth&utm_medium=website&utm_campaign=asnc_2020&utm_content=patient_guide" target="_blank"><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/fae18cdff75ca7a1ac961346cf7af9f2.png" data-image="pod22ybxrm4n" class="img-responsive center-block" alt="Explore Educational Resources for Your Patients" title="custom image"></a><p></p><p><span style="font-size: 20px;"><br></span></p><p><span style="color: rgb(128, 100, 162);"><strong><em><span style="font-size: 20px;"><span style="font-size: 24px;">Find more Lexiscan resources that support the nuclear lab. Click on Resources at the top of this page.</span></span></em></strong></span><br></p><p><span style="color: rgb(128, 100, 162);"><strong><em><br></em></strong></span></p><p><span style="color: rgb(128, 100, 162);"><strong><em><span style="font-size: 24px;"><br></span></em></strong></span><span style="color: rgb(128, 100, 162);"><strong><span style="color: rgb(128, 100, 162);"><span style="font-size: 24px;">IMPORTANT SAFETY INFORMATION (CONTINUED)<br><strong><span style="color: rgb(128, 100, 162);">WARNINGS AND PRECAUTIONS</span></strong></span></span></strong><span style="color: rgb(0, 0, 0);"><span style="font-size: 16px;"><span style="font-size: 20px;"><strong><br></strong><strong>Hypersensitivity, Including Anaphylaxis</strong><strong><br></strong>Anaphylaxis, angioedema, cardiac or respiratory arrest, respiratory distress, decreased oxygen saturation, hypotension, throat tightness, urticaria and rashes have occurred. In clinical trials, hypersensitivity reactions were reported in fewer than 1 percent of patients.</span></span></span></span><strong><span style="font-size: 16px;"><span style="font-size: 20px;"><br></span></span></strong></p><p><span style="font-size: 16px;"><span style="font-size: 20px;"><strong>Hypotension</strong><br>Adenosine receptor agonists, including Lexiscan, induce arterial vasodilation and hypotension. The risk of serious hypotension may be higher in patients with autonomic dysfunction, hypovolemia, left main coronary artery stenosis, stenotic valvular heart disease, pericarditis or pericardial effusions, or stenotic carotid artery disease with cerebrovascular insufficiency. In postmarketing experience, transient ischemic attacks, seizures and syncope have been observed.</span></span></p><p><span style="font-size: 16px;"><span style="font-size: 20px;"><strong>Hypertension</strong><br>Adenosine receptor agonists, including Lexiscan, may result in clinically significant increases in blood pressure in some patients. In postmarketing experience, cases of potentially clinically significant hypertension have been reported, particularly in patients with underlying hypertension and when low-level exercise was included in the MPI.</span></span></p><p><span style="font-size: 16px;"><span style="font-size: 20px;"><strong>Bronchoconstriction</strong><br>Adenosine receptor agonists, including Lexiscan, may cause dyspnea, bronchoconstriction and respiratory compromise. Appropriate bronchodilator therapy and resuscitative measures should be available prior to and following Lexiscan administration.</span></span></p><p><span style="font-size: 16px;"><span style="font-size: 20px;"><strong>Seizure</strong><br>Lexiscan may lower the seizure threshold; obtain a seizure history. New-onset or recurrence of convulsive seizures has occurred following Lexiscan injection. Some seizures are prolonged and require emergent anticonvulsive management. Aminophylline may increase the risk of seizures associated with Lexiscan injection. Methylxanthine use is not recommended in patients who experience a seizure in association with Lexiscan administration.</span></span></p><p><span style="font-size: 16px;"><span style="font-size: 20px;"><strong>Cerebrovascular Accident (Stroke)</strong><br>Hemorrhagic and ischemic cerebrovascular accidents have occurred. Hemodynamic effects of Lexiscan including hypotension or hypertension may be associated with these adverse reactions.</span></span></p><p><span style="font-size: 24px;"><span style="color: rgb(128, 100, 162); font-size: 24px;"><strong>ADVERSE REACTIONS</strong></span><strong><span style="color: rgb(128, 100, 162);"><strong><span style="font-size: 16px;"><span style="font-size: 20px;"><span style="color: rgb(128, 100, 162);"></span></span></span></strong></span></strong></span><span style="font-size: 16px;"><span style="font-size: 20px;"><strong><br></strong>In clinical trials, the most common adverse reactions (≥5%) to Lexiscan were dyspnea, headache, flushing, chest discomfort, angina pectoris or ST-segment depression, dizziness, chest pain, nausea, abdominal discomfort, dysgeusia, and feeling hot. Most adverse reactions began soon after dosing, and generally resolved within approximately 15 minutes, except for headache, which resolved in most patients within 30 minutes. Aminophylline was used as a reversal agent in 3% of patients.</span></span></p><p><span style="font-size: 16px;"><span style="font-size: 20px;">In postmarketing experience, the following additional adverse reactions have occurred: supraventricular tachyarrhythmias, acute coronary syndrome (ACS), tremor, QTc prolongation, abdominal pain in association with nausea, vomiting, or myalgias, diarrhea, fecal incontinence, wheezing and musculoskeletal pain.</span></span></p><p><span style="font-size: 20px;"><strong></strong></span></p><p><span style="font-size: 20px;"><strong><br></strong></span></p><p><span style="font-size: 24px;"><strong>PLEASE SEE ADDITIONAL IMPORTANT SAFETY INFORMATION ABOVE.<br></strong><strong>PLEASE SEE FULL </strong><strong><a href="https://www.astellas.us/docs/lexiscan.pdf?utm_source=branded_booth&utm_medium=website&utm_campaign=asnc_2020&utm_content=pi" target="_blank">PRESCRIBING INFORMATION</a></strong><strong> FOR LEXISCAN.</strong></span></p><p><strong><br></strong></p><p><strong><span style="font-size: 20px;"></span></strong><strong></strong><span style="font-size: 12px;"><strong>REFERENCES: 1.</strong> Lexiscan [package insert]. Northbrook, IL: Astellas Pharma US, Inc. <strong>2.</strong> Astellas. Lexiscan. Data on File. <strong>3.</strong> Adenosine [package insert]. Rockford, IL: Mylan Institutional LLC. <strong>4.</strong> Dipyridamole [package insert]. Lake Forest, IL: Hospira, Inc.</span></p><p><span style="font-size: 12px;"><br></span></p><a href="https://www.astellas.com/us/" target="_blank"><img src="https://cdn1.digitellinc.com/uploads/asnc/directories/7/35571b6cf6630948c406e92f1d37e907.png" data-image="q9jw53rfu23n" class="img-responsive" alt="Astellas is proud to be the elite sponsor of ASNC2020" title="custom image"></a><p><span style="font-size: 12px;"><br>Lexiscan<sup>®</sup> and SIMPLIFY THE STRESS<sup>®</sup> are registered trademarks of Astellas US LLC. Astellas<sup>®</sup> and the flying star logo are registered trademarks of Astellas Pharma Inc.<br>Lexiscan was developed in collaboration with Gilead Palo Alto, Inc. (formerly CV Therapeutics, Inc.).<br>©2020 Astellas Pharma US, Inc. All rights reserved. 012-1552-PM 9/20</span><span style="font-size: 12px;"><br></span></p>